- “… to assess the angiogenic potential of chitosan-glycerol phosphate (GP)-hydroxyethyl cellulose (HEC) binder for injectable bone tissue engineering applications.”1
Researchers from School of Engineering and Materials Science, Queen Mary University of London, in London, England, United Kingdom; and from UCL Institute of Child Health, London, England, United Kingdom; have presented an article titled: “Chitosan-based hydrogels do not induce angiogenesis.”
The researchers from Queen Mary University of London and from UCL Institute of Child Health; have also noted:
- “The angiogenic response of chitosan-GP-HEC combined with and without human bone marrow-derived mesenchymal stem cells (hMSCs) was examined using the chick chorioallantoic membrane (CAM) assay.”
- “Chitosan-GP-HEC gel did not show any angiogenic potential, whereas the presence of hMSCs gave rise to an enhanced angiogenic response when placed on the CAM for 3 days.”
- “Quantitatively, significantly more blood vessel formation was observed for the stem cell-containing group as compared to all other groups (p < 0.05), except for the b-FGF-positive control.”
- “The results indicate that the chitosan-GP-HEC binder does not contribute to enhanced angiogenesis and that the presence of hMSCs enhances angiogenesis.”
