- “CD133, a five-transmembrane molecule, has been found on many types of cancers and determined to be a cancer stem cell biomarker.”1
Researchers from General Surgery Department, Soochow University, Suzhou, Jiangsu, China; Pathology Department, The Second Affiliated Hospital, Suzhou, Jiangsu, China; and Laboratory Animal Center, Soochow University, Suzhou, Jiangsu, China; have presented an article titled: “Anti-human CD133 monoclonal antibody that could inhibit the proliferation of colorectal cancer cells.”
The researchers from General Surgery Department, Soochow University, Suzhou, Jiangsu, China; Pathology Department, The Second Affiliated Hospital, Suzhou, Jiangsu, China; and Laboratory Animal Center, Soochow University, Suzhou, Jiangsu, China; have also noted:
- “In this study a functional anti-human CD133 MAb 6B6 was obtained, and the specificity of this MAb was verified by flow cytometry.”
- “This MAb effectively recognized the CD133 molecule expressed on a series of malignant cell lines.”
- “Immunohistochemistry staining showed the CD133 was expressed on colorectal tumor tissue.”
- “Furthermore, we demonstrated that MAb 6B6 could inhibit the proliferation of Caco-2 cells that were derived from a human colorectal carcinoma.”
- “This functional anti-human CD133 MAb provides a valuable tool for further study of biological functions of cancer stem cell that expressed CD133.”
(1) Chen W, Li F, Xue ZM, Wu HR: Anti-human CD133 monoclonal antibody that could inhibit the proliferation of colorectal cancer cells. Hybridoma (Larchmt). 2010 Aug;29(4):305-10.