Non-viral reprogramming. . “We are moving toward clinically applicable regenerative medicine.”

Michael Longaker MD, Professor of Surgery from Stanford University, has said:

  • “This technique is not only safer, it’s relatively simple …”
  • “It will be a relatively straightforward process for labs around the world to begin using this technique.”
  • “We are moving toward clinically applicable regenerative medicine.”

More from a Release dated February 7, sourced from Stanford University Medical Center:
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Nuclear pore complexes. “… nucleoporins, are also present in the nuclear interior and bind to certain genes, which puts them in a new class of gene regulators.”

Martin Hetzer PhD, Hearst Endowment Associate Professor from Salk Institute’s Molecular and Cell Biology Laboratory has said:

  • “Nuclear pores are not only transport channels but play a role in the organization of the genome and a very direct role in gene expression …”
  • “NPC components, called nucleoporins, are also present in the nuclear interior and bind to certain genes, which puts them in a new class of gene regulators.”

More from a Release dated February 4, sourced from Salk Institute:
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Acute lung injury.

Professor Rick Wetsel PhD, from the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas, Houston, Texas, has indicated … “that an experimental treatment involving transplantable lung cells was associated with improved outcomes in tests on mice with acute lung injury.”

Mice receiving the transplantable lung cells lived longer, sustained less scarring in their lungs and had normal amounts of oxygen in their blood, said

More from a Release dated February 2, sourced from University of Texas Health Science Center at Houston:
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Gap junctions. Direct contact.

Researchers from the Karolinska Institutet in Sweden have indicated “… that stem cells transplanted into damaged or threatened nerve tissue quickly establish direct channels, called gap junctions, to the nerve cells. ”

More from a Release dated February 1, sourced from Karolinska Institutet:
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Stem cell regulation. ‘… regulates both stem cell maintenance and simultaneously supports rapid tissue regeneration.’

Linheng Li PhD, from the University of Kansas School of Medicine, in Kansas City, Kansas; and Hans Clevers MD PhD, from the Hubrecht Institute in Utrecht, Netherlands; have indicated … ‘a model of mammalian adult stem cell regulation that may explain how the coexistence of two disparate stem cell states regulates both stem cell maintenance and simultaneously supports rapid tissue regeneration. ‘

More from a Release dated January 29, sourced from Stowers Institute for Medical Research:
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Bone marrow. “… bone marrow cells to fuse with a patient tissues so that nothing transplanted is rejected …”

Nicholas Zavazava MD PhD, from the University of Iowa, has said:

  • “Our study shows that transplanted bone marrow cells fuse not only with bone marrow cells of the recipient, but with non-hematopoietic cells, suggesting that if we can understand the process of cell fusion better, we may be able to target certain organ injuries with the patient’s own bone marrow cells and repair the tissues …”

More from a Release dated January 28, sourced from Federation of American Societies for Experimental Biology:
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Specialized stem cells. “… two proteins appear to act together in ovarian cancer tissue cells to produce more advanced tumors.”

Yingqun Huang MD, Assistant Professor from the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine, has said:

  • “We found that stopping the expression of two genes–Lin28 and Oct4–reduces ovarian cancer cell growth and survival …”.
  • “This recurrence and drug resistance may be due to the presence of CSCs within the tumors that have the capacity to reproduce and to differentiate into non-CSC tumor cells that repopulate the tumor mass …”
  • “Eliminating these CSCs may be key to successful treatments.”

More from a Release dated January 27, sourced from Yale University:
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Epigenetic memory. “… direct perturbation of the Smad signaling pathway …”

Researchers from the Boston University School of Medicine (BUSM) have indicated that “… the TGFβ-Smad signaling pathway, which is over activated in late-stage cancers, is responsible for the “epigenetic memory” that maintains unique patterns of regulatory DNA hypermethylation causing silencing of critical genes that facilitate breast cancer progression.”

More from a Release dated January 25, sourced from Boston University Medical Center:
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CNS stem cells. Direct isolation. “… sorted/expanded hCNS-SC showed potent engraftment, proliferation, migration, and neural differentiation.”

  • “Stem cells, which are clonogenic cells with self-renewal and multilineage differentiation properties, have the potential to replace or repair damaged tissue.”1

Researchers from StemCells Inc, Sunnyvale, California; Laboratory of Genetics, the Salk Institute, La Jolla, California; and Departments of Pathology and Developmental Biology, Stanford University, Stanford, California; have presented an article titled: “Direct isolation of human central nervous system stem cells.”

The researchers from Sunnyvale, La Jolla, and Stanford have also noted:

  • “… directly isolated clonogenic human central nervous system stem cells (hCNS-SC) from fresh human fetal brain tissue, using antibodies to cell surface markers and fluorescence-activated cell sorting.”
  • “These hCNS-SC are phenotypically 5F3 (CD133)(+), 5E12(+), CD34(-), CD45(-), and CD24(-/lo).”
  • “Single CD133(+) CD34(-) CD45(-) sorted cells initiated neurosphere cultures, and the progeny of clonogenic cells could differentiate into both neurons and glial cells.”
  • “Single cells from neurosphere cultures initiated from CD133(+) CD34(-) CD45(-) cells were again replated as single cells and were able to reestablish neurosphere cultures, demonstrating the self-renewal potential of this highly enriched population.”
  • “Upon transplantation into brains of immunodeficient neonatal mice, the sorted/expanded hCNS-SC showed potent engraftment, proliferation, migration, and neural differentiation.”
(1) Uchida N, Buck DW, He D, Reitsma MJ, Masek M, Phan TV, Tsukamoto AS, Gage FH, Weissman IL: Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14720-5.

Childhood leukemia. “… over 99 per cent of cells in the thymus were killed, but these stem cell-like cells persisted and rapidly recovered.”

Researchers from the Royal Melbourne Hospital and the University of Melbourne in Victoria, Australia have reported “… cells that cause a common type of childhood leukaemia – T cell Acute Lymphoblastic Leukaemia (T-ALL). Targeting of these cells may lead to improved treatments for this disease and help prevent relapse.”

More from a Release dated January 21, sourced from University of Melbourne:
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